Tšenyo ea Lung e bakoang ke Busulfan: Ntho e ngoe le e ngoe eo u hlokang ho e tseba ka mafu a sa tloaelehang leholimong a pinki

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Filimi e ncha ea Bollywood 'Sky Is Pink' e litabeng ka mabaka ohle a nepahetseng. Ho ipapisitsoe le pale ea 'nete ea bophelo ba Aisha Chaudhary, filimi e shebana le boemo bo sa tloaelehang ba bongaka, tšenyo ea matšoafo e bakoang ke Busulfan kapa pulmonary fibrosis e ileng ea baka lefu la tšohanyetso la Aisha a le monyane lilemong tsa 18.

O hlahile a e-na le immunodeficiency e matla e kopaneng (SCID), ngoananyana o ile a koptjoa ho kenoa mokong ha a le likhoeli tse 6, ha a ne a fuoa Busulfan (sethethefatsi sa mofets'e). Moriana ona o ile oa tsoela pele ho baka pulmonary fibrosis e leng litlamorao tse sa tloaelehang tsa meriana.

Pele re utloisisa hore na tšenyo ea matšoafo e bakoang ke Busulfan le lintlha tsa eona ke eng, ha re shebeng SCID.

Ke eng e kopantsoeng ea ho itšireletsa mafung (SCID)?

Boloetse bo sa tloaelehang ba liphatsa tsa lefutso, SCID e khetholloa ke kholo e ferekanyang ea lisele tsa T tse sebetsang le lisele tsa B, ka lebaka la liphetoho tse ngata tsa lefutso. Boemo bona bo etsa hore ngoana a theole haholo kapa a se ke a itšireletsa mafung ho hang, a etsa hore mmele oa ngoana o tšoaroe ke mafu a mefuta e fapaneng ^{[1] [pedi]} .

Bana ba nang le lefu lena le sa tloaelehang, le futsitsoeng ba kula haholo ka mafu a kang pneumonia, meningitis, le khōhō 'me ba ka shoa pele selemo sa pele sa bophelo ba bona. Leha ho le joalo, mekhoa ea sejoale-joale ea bongaka le kalafo e thusitse ntlafatso.

Ho kenyelletsa mongo oa masapo ke kalafo e sebetsang ka ho fetisisa bakeng sa SCID ^[3] .

Joale, Ho Fetoha Bone Marrow Ke Eng?

Ho kenyelletsa 'moko oa masapo ke kalafo e nkang sebaka sa' moko o seng bophelo bo botle ka e phetseng hantle. Moko oa masapo ke lisele tse bonolo tse spong ka har'a masapo a hau tse etsang lisele tse etsang mali (lisele tsa mali) tse fetohang lisele tsa mali ho loants'a ts'oaetso, li tsamaisa oksijene 'meleng oohle le ho laola ho tsoa mali ^[4] .

Kamohelo e etsoa ho kenya lisele tsa moko oa 'mele tse phetseng hantle ka mor'a hore moko oa masapo o sa pheleng o tlosoe,' me ho molemo ho ntlafatsa sesole sa 'mele sa ngoana ^[5] .

Hammoho le melemo e mengata eo keketso e nang le eona ho ntlafatseng bophelo ba motho, e boetse e na le mathata a 'maloa a kang lefu la ho hlomathisa khahlanong le lefu, ho hloleha ha lisele tsa bakoang, tšenyo ea setho, tšoaetso, lera la mahlo, ho hloka thari, mofetše o mocha esita le lefu ^{[6] [1]} .

Busulfan ke sethethefatsi se khahlanong le mofets'e se sebelisoang ts'ebetsong ea phetisetso ea moko oa masapo. Leha ho le joalo, ho bile le litlaleho tsa hore sethethefatsi sena se na le phello e mpe ho batho ba ileng ba fetisoa, 'me pulmonary fibrosis e le eona e matla ka ho fetisisa.

Kaha joale re se re koahetse mabaka, ha re shebeng sehlooho sa mantlha, 'Tšenyo e bakoang ke matšoafo a Busulfan' mme bakeng sa seo, re hloka ho tseba hore na Busulfan ke eng le hore e sebetsa joang ^[7] .

Busulfan ke eng?

Ke moriana oa ngaka o sebelisetsoang ho alafa kankere le ho senya moko oa masapo o sa batleheng pele ho kenyelletsoa moko oa masapo. Moriana oa chemotherapy ke oa sehlopha sa lithethefatsi se bitsoang alkylating agents mme o sebetsa ka ho fokotsa kapa ho emisa kholo ea lisele tsa mofetše 'meleng oa hau. ^[8] . E boetse e sebelisetsoa ho alafa mathata a itseng a mali a kang polycythemia vera le myeloid metaplasia le ho phekola leukemia e sa foleng ea myelogenous (CML) ^[9] .

Leha ho le joalo, sethethefatsi sa chemotherapy, joalo ka ha ho boletsoe kaholimo, se na le litlamorao tse mpe tse bakang pulmonary fibrosis e bitsoang tšenyo ea matšoafo e bakoang ke Busulfan ^{[9] [10]} .

Tšenyo ea Busulfan Lung ke eng?

Busulfan lung, eo ho thoeng ke 'pulmonary fibrosis' e bakoa ke moriana moo lisele tsa matšoafo li senyehang le ho ba le mabali. Le ha e le ntho e sa tloaelehang, boemo bona boa bolaea 'me bo hlaha ka tlase ho liperesente tse 5 tsa bakuli ba kileng ba alafshoa le Busulfan ^{[leshome le motso o mong]} . Tlaleho ea pele ea tšenyo ea matšoafo ea Busulfan e tlalehiloe ka 1961.

Boemo bona bo etsa hore likhoele tse thata le tse thata li thehoe matšoafong, e leng se etsang hore ho be thata hore motho a heme.

Empa, hoa lokela ho hlokomeloa hore setlhare se na le litla-morao tse ling tse matla joalo ka tse latelang ^[12] :

• Ho tsoa madi
• Ho hloka matla
• Cataract
• Testrophy atrophy
• Amenorrhoea
• Ho senyeha ha lesea ka popelong
• Nyopa
• Fibrosis ea pulmonary
• Ho beoa ha uric acid ho li-tubules tsa liphio
• Khaello ea mali
• Alopecia
• Gynaecomastia

Tse ling tsa litla-morao tse bobebe tsa moriana ke tse latelang ^{[leshome le motso o mong]} :

• Ho fokotsa boima ba 'mele
• Ho nyekeloa
• Ho fetoloa letlalo ka bongata
• Ho hlatsa
• Letšollo
• Li-rash
• Mokhathala
• Molomo o omileng

Tšenyo ea Busulfan Lung e Tsejoa Joang?

Ha re nahana hore boemo bo bakoa ke moriana, ho thata ho tseba hore na o na le bothata bofe. Maemong a mangata, boemo bo tla ba boemong ba bona bo tsoetseng pele.

High-resolution computed tomography (CT Scan) le histopathology ke mekhoa e haufi haholo e ka thusang ho fumana boemo ^[13] . Maemong a mang a tšenyo ea matšoafo a Busulfan, litlhahlobo li senotse tse latelang:

• Phokotso ea ho lokolla carbon monoxide (CO)
• Mokhoa o thibelang ho hema ha ho etsoa liteko tsa tšebetso ea pulmonary
• X-ray ea sefuba e ka bonts'a mabala le mabala ka mahlakore ka bobeli a matšoafo
• Boteng ba rales
• Mmala o moputsoa oa molomo, letlalo kapa manala ka lebaka la maemo a tlase a oksijene ea mali
• Keketseho e sa tloaelehang ea setsi sa manala

Ka Tsebiso ea ho Qetela ...

Haeba boemo bo tšoaroa methating ea pele, ho bonolo haholo ho sebetsana le pulmonary fibrosis e bakoang ke lithethefatsi - joalo ka ha kalafo ea hona joale ea lithethefatsi e ka emisoa mme ho ka qaloa meriana e mecha. ^{[14] [leshome le metso e mehlano]} .

Leha ho le joalo, lithuto tse ling li lokela ho etsoa ho utloisisa boemo ba lefu le bakoang ke moriana le ho nts'etsapele kalafo e sebetsang e tšoanang.

1. [1]De Ravin, S. S., Wu, X., Moir, S., Kardava, L., Anaya-O'Brien, S., Kwatemaa, N., ... & Marquesen, M. (2016). Phekolo ea liphatsa tsa lefutso tsa Lentiviral hematopoietic stem cell bakeng sa X e amanang haholo le immunodeficiency e kopaneng. Meriana ea phetolelo ea mahlale, 8 (335), 335ra57-335ra57.
2. [pedi]Palacios, T. V., Vergales, B., Wisniewski, J., Borish, L., & Lawrence, M. G. (2016). Phihlelo ea Univesithi ea Virginia ea ho kenya tšebetsong tlhahlobo ea masea e sa tsoa tsoaloa bakeng sa immunodeficiency e matla e kopaneng (SCID). Tlaleho ea Allergy le Clinical Immunology, 137 (2), AB216.
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7. [7]Ikeda, J., Scipione, C., Hyduk, S., Althagafi, M. G., Gao, X., Jongstra-Bilen, J., & Cybulsky, M. I. (2019). Phetoho ea Bone Marrow e ama karolo ea khale ka ho fetesisa ea sebopeho sa Atherosclerotic Lesion. Arteriosclerosis, Thrombosis, le Biology ea Vascular, 39 (Suppl_1), A534-A534.
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